This is the way we’ve been doing medical research for decades.
These traditional fixed designs are helpful in some areas of medical research, but not for all. Complex diseases and health conditions often have multiple unanswered questions, multiple treatment options and complicated patient subgroups. In this context, conducting research in this traditional way can take too long, be expensive and generate more questions that cannot be answered, greatly affecting translation of evidence into medical care. In patient populations where there is an urgent need for information and where the stakes and costs can be high, other methods of conducting medical research are needed.